Inhibitory Effect of Aminobenzoic Add Derivatives on Hemolytic Reaction in Vitro

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Abstract
Some derivatives of aminobenzoic acid were examined for their inhibitory activity against immune hemolysis and heat-induced hemolysis. Of the compounds tested, bis-(salicylamido)benzoic acids had a potent inhibitory effect on both hemolytic reactions. In immune hemolysis, inhibitory activity of 2,4- and 2,5-bis(salicylamido)benzoic acid was a little weaker than that of sodium copper-chlorophyllin, but stronger than that of sodium citrate, dipotassium EDTA, and non-steroidal anti-inflammatory drugs used as active controls. In heat-induced hemolysis, 2,4- 3,5- and 2,5-bis(salicylamido)benzoic acid inhibited hemolytic reactions more than non-steroidal anti-inflammatory drugs. Structure-activity relationships and possible use of these active compounds as new drugs were discussed.

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