Differential Expression of DRw52‐Like Determinants Detected by Monoclonal Antibodies
- 1 February 1987
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 25 (2) , 127-131
- https://doi.org/10.1111/j.1365-3083.1987.tb01055.x
Abstract
The reactivity of three monoclonal antibodies (MoAb) directed against DWw52-like determinants was studied in relation to the reactivity of an anti-DR MoAb using fluorescence-activated cell sorter (FACS) analysis. The MCS-7 MoAb reacted with all DRw52+ cells and in addition with DR2+, DR4+, and a DR7+ cell. Both the I-LR2 and the 7.3.19.1 MoAb reacted with DR3+, DR5+, and DRw6+ cells only. However, whereas the 1-LR2 MoAb reacted strongly with all those cells compared with the anti-DR MoAb, the 7.3.19.1 MoAb reacted strongly with DR3+ cells only, and somewhat less with DR5+ and DRw6+ cells. The implications of this for the location of DRw52-like determinants on DR.beta. chains is discussed.This publication has 10 references indexed in Scilit:
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