The contribution of N-glycans and their processing in the endoplasmic reticulum to glycoprotein biosynthesis

Open Access

17 April 2003

journal article
review article
Published by Oxford University Press (OUP) in Glycobiology

Vol. 13 (9) , 77R-91
https://doi.org/10.1093/glycob/cwg075

Abstract

The attachment of N-glycans to nascent glycoproteins in the endoplasmic reticulum (ER) is intimately related to glycoprotein biogenesis. Processing of N-linked oligosaccharides begins in the ER and participates in glycoprotein folding and assembly. The elucidation of N-glycan processing mechanisms in the ER is uncovering their role in glycoprotein biosynthesis.

Keywords

DEGRADATION
FOLDING
GLYCOPROTEIN
PROCESSING
TRANSPORT
CNX
CALNEXIN
CRT
CLARETICULIN
ENDOPLASMIC RETICULUM
ERAD
ER-ASSOCIATED DEGRADATION
ERGIC
ER-GOLGI INTERMEDIATE COMPARTMENT
UDP-GLC: GLYCOPROTEIN GLUCOSYLTRANSFERASE
UPR
UNFOLDED PROTEIN RESPONSE

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