Mebendazole

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Abstract
Mebendazole (Vermox, Belgium), a new anthelmintic drug, was tested in Louisiana subjects infected with whipworms (Trichuris trichiura) and pinworms (Enterobius vermicularis). For comparative purposes, groups of patients infected with whipworms and pinworms were treated with thiabendazole (Mintezol) and pyrvinium pamoate (Povan), respectively. Mebendazole proved to be highly effective against whipworms in a three-day treatment course. The drug was relatively ineffective as a single-dose treatment, as was thiabendazole when administered in the recommended two-day treatment course. We found mebendazole to be at least as effective as pyrvinium pamoate against pinworm infections when both were administered as single doses. Mebendazole was found to be free of notable side effects and, in our opinion, is the current drug of choice for treatment of whipworm and pinworm infections. (JAMA230:1412-1414, 1974)

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