Syntheses and Antibacterial Activities of Tizoxanide, an N-(Nitrothiazolyl)salicylamide, and its O-Aryl Glucuronide
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Chemical Research
- No. 1,p. 44-45
- https://doi.org/10.1039/a806676k
Abstract
Mild hydrolysis of the broad-spectrum anaerobic antibacterial and antiparasitic agent nitazoxanide 1 affords tizoxanide 2, which is a major metabolite of 1 retaining most of its activity; further metabolism of 2 leads to the O-aryl glucuronide 3, efficiently synthesised in four steps from benzyl salicylate and showing slight antibacterial activity.Keywords
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