THE ACTION OF EXCESS Na, Ca and K ON THE CORONARY VESSELS

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Abstract
Langendorff preparations of dog hearts with ventricles fibrillating were perfused under constant pressure and constant temperature with defibrinated heparinized dog blood containing 10 cc. of 10% calcium gluconate and 3 grams glucose. The chlorides of sodium, calcium and potassium dissolved in small amounts of distilled water were either injected directly into the coronary inflow tubing or added to the perfusion reservoir, and the effect on coronary flow noted. Na and Ca produced a dilatation of the coronary vessels; the effect of the latter being longer in duration. K in dilute concns. produced a brief dilatation; in stronger concns., a long-lasting constriction, at times almost to the point of complete coronary occlusion.

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