Major Depressive Disorder
Top Cited Papers
- 3 January 2008
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 358 (1) , 55-68
- https://doi.org/10.1056/nejmra073096
Abstract
This review of major depressive disorder is a comprehensive account of the genetic, biochemical, and neurophysiological changes that have been implicated in the disorder. No single mechanism can account for all the clinical variations in this condition. The monoamine oxidase theory can explain many of the actions of antidepressants, but genetic factors, stress, and psychosocial factors also play a part in depression.Keywords
This publication has 119 references indexed in Scilit:
- VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressantsProceedings of the National Academy of Sciences, 2007
- Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memoriesMolecular Psychiatry, 2007
- Effects of Citalopram and Interpersonal Psychotherapy on Depression in Patients With Coronary Artery DiseaseJAMA, 2007
- Early Onset of Selective Serotonin Reuptake Inhibitor Antidepressant ActionArchives of General Psychiatry, 2006
- GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major DepressionNeuropsychopharmacology, 2006
- Neocortical neurogenesis in humans is restricted to developmentProceedings of the National Academy of Sciences, 2006
- The circadian basis of winter depressionProceedings of the National Academy of Sciences, 2006
- Epigenetic programming by maternal behaviorNature Neuroscience, 2004
- Nicotine and nicotinic receptor antagonists potentiate the antidepressant‐like effects of imipramine and citalopramBritish Journal of Pharmacology, 2003
- The Corticosteroid Receptor Hypothesis of DepressionNeuropsychopharmacology, 2000