Meningioma with hypergammaglobulinemia

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Abstract
The case of a 14-year-old boy presenting with hypergammaglobulinemia (immunoglobulin (Ig)G and IgA) and a cerebellopontine angle tumor is reported. The tumor was histologically confirmed as meningioma infiltrated with plasma cells, lymphocytes, and histiocytes. Immunohistochemical studies showed that the infiltrating plasma cells were stained by antibodies to IgG and IgA. After total tumor removal, the hypergammaglobulinemia immediately resolved. A plausible interpretation of this sequence of events is that the inflammatory cell reaction to the meningioma caused the immunological response followed by an unusual hypergammaglobulinemia.