Highly enantioselective asymmetric autocatalysis of 2‐alkenyl‐ and 2‐vinyl‐5‐pyrimidyl alkanols with significant amplification of enantiomeric excess
- 1 January 2002
- Vol. 14 (2-3) , 166-168
- https://doi.org/10.1002/chir.10068
Abstract
2‐Alkenyl‐ and 2‐vinyl‐5‐pyrimidyl alkanols are highly enantioselective asymmetric autocatalysts with significant amplification of enantiomeric excess in the enantioselective addition of diisopropylzinc to 2‐alkenyl‐ and 2‐vinylpyrimidine‐5‐carbaldehydes. Consecutive asymmetric autocatalysis starting from 7% ee increases the ee of pyrimidyl alkanol up to 99% without the need for any other chiral auxillary. Chirality 14:166–168, 2002.Keywords
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