A Modified Thermal Deposition Unit for Gel-Permeation Chromatography with Matrix-Assisted Laser Desorption/Ionization and Electrospray Ionization Time-of-Flight Analysis
- 1 October 2002
- journal article
- Published by SAGE Publications in European Journal of Mass Spectrometry
- Vol. 8 (5) , 397-401
- https://doi.org/10.1255/ejms.500
Abstract
We describe a modified commercially available thermal deposition unit that incorporates a post-column mixing cell for gel-permeation chromatography (GPC) effluent and matrix solution prior to continuous deposition onto a matrix-assisted laser desorption/ionization (MALDI) sample target. This modification overcomes the shortcomings of using a prefabricated matrix foil. This GPC MALDI method with time-of-flight (ToF) mass spectrometry is demonstrated by the analysis of a poly(dimethylsiloxane) (PDMS) sample used in the production of implantable device materials.Keywords
This publication has 7 references indexed in Scilit:
- Detailed analysis of α,ω-bis(4-hydroxybutyl) poly(dimethylsiloxane) using GPC-MALDI TOF mass spectrometryJournal of the American Society for Mass Spectrometry, 2002
- Characterization of Silicone Rubber Extracts Using Gel-Permeation Chromatography, Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Electrospray Ionization Mass Spectrometry, Fourier Transform Infrared Spectroscopy and Gas Chromatography/Mass SpectrometryEuropean Journal of Mass Spectrometry, 2001
- Mass Spectrometry of Polymers and Polymer SurfacesChemical Reviews, 2001
- Direct sample fraction deposition using electrospray in narrow-bore size-exclusion chromatography/matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for polymer characterizationJournal of Mass Spectrometry, 2000
- GPC Separation of Polymer Samples for MALDI AnalysisAnalytical Chemistry, 2000
- Polymer Analysis by Micro-Scale Size-Exclusion Chromatography/MALDI Time-of-Flight Mass Spectrometry with a Robotic InterfaceAnalytical Chemistry, 1998
- A Direct Deposition Method for Coupling Matrix-assisted Laser Desorption/Ionization Mass Spectrometry with Gel Permeation Chromatography for Polymer CharacterizationRapid Communications in Mass Spectrometry, 1997