EXPERIMENTAL SMALL BOWEL TRANSPLANTATIONUTILIZING Cyclosporine

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Abstract
Cyclosporine prolonged the survival of ectopic smallbowel allografts in a canine model. A 9-fold increase inmean survival as compared with controls was obtained. Addition of prednisone to cyclosporine did not result infurther graft prolongation, but improved the gross and histological appearance of the allograft. Monitoring the motility and histology of the allograft appears to beautiful in predicting approaching rejection. Xylose absorption was not helpful in this regard. A new technique for measuring fat absorption in the transplant is described. Following allografting, fat absorption is resumed by 14 days posttransplantation.

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