Rational Design of Inhibitors of HIV-1 TAR RNA through the Stabilisation of Electrostatic “Hot Spots”
- 7 January 2004
- journal article
- Published by Elsevier in Journal of Molecular Biology
- Vol. 336 (2) , 343-356
- https://doi.org/10.1016/j.jmb.2003.12.046
Abstract
No abstract availableKeywords
This publication has 60 references indexed in Scilit:
- RNA as a Target for Drug Design, the Example of Tat-TAR InteractionCurrent Topics in Medicinal Chemistry, 2002
- Ribosome Structure and the Mechanism of TranslationPublished by Elsevier ,2002
- 2 RNA as a Drug TargetProgress in Medicinal Chemistry, 2002
- Targeting RNA with Small-Molecule Drugs: Therapeutic Promise and Chemical ChallengesAccounts of Chemical Research, 2001
- Methylphosphonate mapping of phosphate contacts critical for RNA recognition by the human immunodeficiency virus tat and rev proteinsNucleic Acids Research, 1994
- Hydrogen-bonding Contacts in the Major Groove are required for Human Immunodeficiency Virus Type-1 tat Protein Recognition of TAR RNAJournal of Molecular Biology, 1993
- High Affinity Binding of TAR RNA by the Human Immunodeficiency Virus Type-1 tat Protein Requires Base-pairs in the RNA Stem and Amino Acid Residues Flanking the Basic RegionJournal of Molecular Biology, 1993
- RNA recognition by Tat-derived peptides: Interaction in the major groove?Cell, 1991
- Fragments of the HIV-1 Tat Protein Specifically Biand TAR RNAScience, 1990
- Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.Proceedings of the National Academy of Sciences, 1989