PROLONGED ACTION OF HISTAMINE

Abstract
The secretory response of gastric pouches of dogs to inj. of histamine in a mixture of beeswax and mineral oil lasted 24 hrs. or more, as compared with 41/2 hrs. or less when histamine in saline soln. was injected. The volume of secretion when histamine in beeswax was used was 8-16 times that when histamine in saline soln. was used. A mixture of beeswax and mineral oil without histamine had little or no effect on gastric secretion.

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