Synthesis and 1H‐, 13C‐NMR analysis of some substituted 1,2,3,4‐tetrahydroisoquinolines
- 1 July 1989
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 26 (4) , 907-911
- https://doi.org/10.1002/jhet.5570260405
Abstract
Synthesis and 1H‐, 13C‐nmr analysis of some substituted 3‐phenyl‐1,2,3,4‐tetrahydroisoquinolines are reported. Spectroscopy assignments of hydrogen and carbon resonances were made on the basis of standard chemical shift theory, comparison with reference compounds, attached proton test and fully coupled 13C‐nmr spectra. Data showed that at room temperature two conformers predominated for the 1,3‐disubstituted and 1,2,3‐trisubstituted isoquinolines.Keywords
This publication has 10 references indexed in Scilit:
- Simple Isoquinoline AlkaloidsJournal of Natural Products, 1986
- Stereochemistry of intramolecular amidoalkylation reactions in the synthesis of polycyclic isoquinoline derivativesThe Journal of Organic Chemistry, 1983
- 13C NMR Analysis of some simple tetrahydroisoquinolinesPhytochemistry, 1983
- Carbon‐13 nuclear magnetic resonance spectra of isoquinoline alkaloidsJournal of Heterocyclic Chemistry, 1978
- 13C NMR spectral analysis of some isoquinoline alkaloidsPhytochemistry, 1978
- Synthesis of cis- and trans-1-(3,4-dimethoxybenzyl)-3,7-dimethyl-5,8-dimethoxy-1,2,3,4-tetrahydroxyisoquinoline. Mechanism of the Bischler-Napieralski reactionThe Journal of Organic Chemistry, 1974
- The conformational analysis of saturated heterocycles. Part LXVII. 2-Alkyl-3,6-dihydro-2H-1,2-oxazines and 3-alkyl-3,4-dihydro-1H-2,3-benzoxazinesJournal of the Chemical Society, Perkin Transactions 2, 1974
- Conformations of tetra- and hexahydropyridazines. Slow ring inversion and slow nitrogen inversionJournal of the American Chemical Society, 1969
- Hindered rotation in substituted 1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolinesJournal of the American Chemical Society, 1969
- Hindered Rotation in 1-Benzyl-1,2,3,4-tetrahydro-6-7-dimethoxyisoquinolinesJournal of the American Chemical Society, 1967