Induction of autoimmune disease by graft-versushost reaction across MHC class II difference: modification of the lesions in IL-6 transgenic mice
Open Access
- 1 March 1994
- journal article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 95 (3) , 525-529
- https://doi.org/10.1111/j.1365-2249.1994.tb07030.x
Abstract
We examined the effect of IL‐6 on the development of autoimmune diseases (primary biliary cirrhosis. Sjögren's syndrome) employing murine grari‐versus‐host reaction (GVHR) model with MHC class II disparity. For this purpose, we used IL‐6 transgenic(B6.6) mice in which a high level of IL‐6 was detected. C57B1/6 (B6) spleen T cells were injected into B6.6 mated with B6.C‐H‐2(bml2) mutant mice ((bmi2x B6.6)FI) and GVHR with MHC class II disparity was induced. The iransgenic hybrid mice with GVHR showed a larger spleen index and contained a higher serum level of IL‐6 than those without GVHR. Autoimmune‐like lesions in transgenic recipients became weakened compared with those in non‐transgenic (bml2 x B6)F1 recipients. In contrast, levels of antimitochondrial antibodies in (bm 12 x B6.6)FI GVHR group were signiiicantly higher than that of (bml2 X B6)FI GVHR group. These results indicate that lL‐6 excessively produced in vivo might regulate the progression of autotmmune diseases.Keywords
This publication has 27 references indexed in Scilit:
- Biological and clinical aspects of interleukin 6Immunology Today, 1990
- Detection of Autoantibodies to Recombinant Mitochondrial Proteins in Patients with Primary Biliary CirrhosisNew England Journal of Medicine, 1989
- Hepatic lesions induced by graft-versus-host reaction across MHC class II antigens: An implication for animal model of primary biliary cirrhosisClinical Immunology and Immunopathology, 1988
- Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritidesArthritis & Rheumatism, 1988
- Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2‐dependent cell line and preparation of anti‐IL 6 monoclonal antibodiesEuropean Journal of Immunology, 1988
- The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.The Journal of Experimental Medicine, 1988
- Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferationCell, 1986
- Antimitochondrial antibodies in primary biliary cirrhosisJournal of Hepatology, 1986
- Corticotropin-Releasing Activity of MonokinesScience, 1985
- Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseasesImmunology Today, 1984