MDM2 — master regulator of the p53 tumor suppressor protein
Top Cited Papers
- 1 January 2000
- Vol. 242 (1-2) , 15-29
- https://doi.org/10.1016/s0378-1119(99)00487-4
Abstract
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This publication has 119 references indexed in Scilit:
- An Inhibitor of Nuclear Export Activates the p53 Response and Induces the Localization of HDM2 and p53 to U1A-Positive Nuclear Bodies Associated with the PODsExperimental Cell Research, 1999
- p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53Oncogene, 1999
- Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53The EMBO Journal, 1999
- Regulation of p53 stability by Mdm2Nature, 1997
- Mdm2 promotes the rapid degradation of p53Nature, 1997
- Transgenic mice with p53-responsive lacZ: p53activity varies dramatically during normal development and determines radiation and drug sensitivity invivoThe EMBO Journal, 1997
- p53 Protein Exhibits 3′-to-5′ Exonuclease ActivityCell, 1996
- The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING fingerTrends in Biochemical Sciences, 1994
- Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53Nature, 1993
- p53 is required for radiation-induced apoptosis in mouse thymocytesNature, 1993