Does Verapamil Influence Glucose‐Induced Insulin Release in Man?

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Abstract
The effect of verapamil on the tolerance for oral glucose and on the pancreatic release of insulin was investigated in 6 normoglycemic patients admitted to hospital because of abdominal diseases. Each patient was studied twice. On one occasion, 100 g glucose was ingested during simultaneous i.v. infusion of verapamil, on the other, glucose was given during i.v. infusion of saline. Blood samples for insulin and glucose measurements were collected simultaneously via a portal and an antecubital vein catheter. It was found that the blood glucose and serum insulin responses to oral glucose were unaffected by verapamil both in the portal and in the peripheral venous blood. These findings imply that the pancreatic release of insulin, the tolerance for oral glucose, and the intestinal absorption of glucose remain unaffected by i.v. verapamil in normoglycemic individuals.