Natural and recombinant human interleukin 1-beta is cytotoxic for human melanoma cells.
Open Access
- 15 April 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 136 (8) , 3098-3102
- https://doi.org/10.4049/jimmunol.136.8.3098
Abstract
Human peripheral blood monocytes stimulated with LPS were found to release an activity that was cytotoxic for the A375 melanoma. Biochemical and immunological characterization of the activity indicated that IL 1-beta was the cytotoxic agent. Human recombinant IL 1-beta, purified to homogeneity, was directly cytotoxic for A375. Tumor necrosis factor, also released by activated monocytes, was not cytotoxic for the A375 melanoma.This publication has 4 references indexed in Scilit:
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- LYSIS OF TUMOR-CELLS BY HUMAN-BLOOD MONOCYTES BY A MECHANISM INDEPENDENT OF ACTIVATION OF THE OXIDATIVE BURST1985
- Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.Proceedings of the National Academy of Sciences, 1984
- Stimulation of Muscle Protein Degradation and Prostaglandin E2Release by Leukocytic Pyrogen (Interleukin-1)New England Journal of Medicine, 1983