Recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers
- 1 September 2001
- journal article
- clinical trial
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 52 (3) , 333-336
- https://doi.org/10.1046/j.0306-5251.2001.01453.x
Abstract
Aims To study the recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers.Methods Ten healthy volunteers were treated with clopidogrel (75 mg day−1) for 7 days. CD62P expression and PAC‐1 binding were measured by flow cytometry.Results Adenosine diphosphate (ADP, 30 µM)‐induced platelet responses were almost completely inhibited by clopidogrel. After discontinuation of the drug, platelet function gradually increased and complete recovery was seen 7 days after the last clopidogrel dose. The mean difference (95% CI) for ADP‐induced PAC‐1 binding (fluorescence intensity) between baseline and 7 days after the last dose was 0.01 (0.61, −0.59). Single cell analysis provides direct evidence for an irreversible mode of action of clopidogrel.Conclusions This is the first report to directly demonstrate irreversibility of clopidogrel action in humans.Keywords
This publication has 14 references indexed in Scilit:
- Identification and biological activity of the active metabolite of clopidogrel.2000
- PlateletsThe Lancet, 2000
- Ticlopidine and ClopidogrelCirculation, 1999
- Specific Impairment of Human Platelet P2Y AC ADP Receptor–Mediated Signaling by the Antiplatelet Drug ClopidogrelArteriosclerosis, Thrombosis, and Vascular Biology, 1999
- Non-specific inhibition of ADP-induced platelet antiaggregation by clopidogrel in vitro.1999
- Specific inhibition of ADP‐induced platelet aggregation by clopidogrel in vitroBritish Journal of Pharmacology, 1999
- Repeated-dose pharmacodynamics of clopidogrel in healthy subjects.1999
- Pharmacokinetic profile of 14C-labeled clopidogrel.1999
- ClopidogrelDrugs, 1997
- Platelet Flow Cytometry — Adhesive ProteinsPublished by Springer Nature ,1997