An additional susceptibility gene for juvenile idiopathic arthritis in the HLA class I region on several DR‐DQ haplotypes

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Abstract
Juvenile idiopathic arthritis (JIA) is an HLA‐associated rheumatic disease with onset in childhood. We recently reported that allele 5 at microsatellite D6S265 in the HLA class I region is associated with JIA, independent of linkage disequilibrium with the high risk DR8‐DQ4 haplotype. In the present study, we investigated whether alleles at D6S265, or other markers in this region, also modify the risk for JIA on other haplotypes, i.e., DRB1*1301‐DQB1*0603 or DRB1*1101/4‐DQB1*0301. We observed a significant association with allele 6 at D6S265 on the DRB1*1301‐DQB1*0603 haplotype. We also noted an association with allele 3 at D6S265, when carried on the DRB1*1101/4‐DQB1*0301 haplotype. Our results further support an additional JIA susceptibility gene in the HLA class I region in linkage disequilibrium with alleles at D6S265.