Inhibitory Effect of Retinoids on Epstein-Barr Virus Induction in Raji Cells

Abstract
Induction of Epstein-Barr virus (EBV) early antigen after treatment with various combinations of croton oil and π-butyrate was markedly inhibited by retinoids 7901, 7902, Ro 10-9359 and Ro 11-1430. Possible administration of retinoids to virus capsid antigen IgA antibody-positive individuals in high-risk areas for nasopharyngeal carcinoma to prevent EBV activation and development of this cancer is discussed.

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