Ebolavirus VP35 Interacts with the Cytoplasmic Dynein Light Chain 8
Open Access
- 1 July 2009
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 83 (13) , 6952-6956
- https://doi.org/10.1128/jvi.00480-09
Abstract
The viral protein VP35 of ebolavirus (EBOV) is implicated to have diverse roles in the viral life cycle. We employed a yeast two-hybrid screen to search for VP35 binding partners and identified the cytoplasmic dynein light chain (DLC8) as a protein that interacts with VP35. Mapping analysis unraveled a consensus motif, SQTQT, within VP35 through which VP35 binds to DLC8. The disruption of DLC8 binding does not affect the ability of VP35 to inhibit type I IFN production. Given that VP35 from various EBOV species interacts with DLC8, this interaction may have a role in regulating the EBOV life cycle.This publication has 33 references indexed in Scilit:
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