Difference in clinical features and HLA antigens between familial and non-familial vitiligo of non-segmental type
- 1 October 1993
- journal article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 129 (4) , 408-410
- https://doi.org/10.1111/j.1365-2133.1993.tb03167.x
Abstract
Of 131 patients with non-segmental vitiligo studied, 29 (22%) had a family history of this disorder. The clinical features and HLA antigens were assessed, and a comparison made between patients with familial and those with non-familial, non-segmental vitiligo. Familial patients developed skin lesions significantly earlier than non-familial patients. There was a significant association between HLA-B46 and familial non-segmental vitiligo, whereas HLA-A31 and CW4 were found in non-familial patients. The differences in clinical features and HLA phenotypes suggest heterogeneity in the pathogenic process between familial and non-familial vitiligo patients.Keywords
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