The effects of blocking agents upon the isolated vas deferens of the guinea-pig stimulated by the hypogastric nerve

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Abstract
When the guinea-pig isolated vas deferens preparation was stimulated by its hypogastric nerve, the responses obtained at different frequencies of stimulation were all reduced proportionately by guanethidine, bretylium, reserpine and pentamethonium. The difference between guanethidine and bretylium in affecting the responses to nervous stimulation at different frequencies of the cat nictitating membrane reported by Boura & Green was not observed with this preparation. Papaverine reduced responses to high frequencies of stimulation more than those to low frequencies. Amphetamine also reduced responses to all frequencies uniformly except in the smallest doses used, which potentiated the responses to high frequencies; these doses reversed the reduction in response by guanethidine, bretylium and reserpine. Preparations stimulated between parallel electrodes responded similarly to those stimulated by the hypogastric nerve.