Corneal Edema with Hydrogel Lenses and Eye Closure

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Abstract
Several investigators reported that significant corneal edema develops when daily wear hydrogel lenses are worn with the eyes closed. The amount of edema that developes when extended wear hydrogel lenses are worn with eye closure is not well documented. This study compared the amount of corneal edema that developed when subjects [human] wore 1 daily wear lens with the edema that developed when they wore 3 lens types designed for extended wear. The daily wear lens was the U3 series Bausch and Lomb Soflens contact lens. The extended wear lenses were the Cooper Permalens, the Soft Lens Hydrocurve II 55 lens and the Sauflon PW lens. The 5 subjects developed only small amounts of corneal edema when they wore the 4 lens types under opened-eye conditions, but they developed significant amounts of corneal edema when they wore the 4 lens types for 3-h periods with eye closure. The amount of corneal edema correlated well with the O2 transmissibility (DK/L) of the study lenses. The results can be used to predict the amount of corneal edema that the average patient will develop initially when wearing a hydrogel lens of known water content or O2 permeability (DK) and thickness (L) under opened and closed-eye conditions.

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