Influences upon the Agglutinability of Rabbit Erythrocytes in the Presence of Iso-Antibody: Genetic Factors

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Abstract
Summary: The strength of reaction of a cell, when measured by quantitative hemagglutination tests, may be influenced by factors in addition to gene dosage. Reactions may be regulated by competition between alleles for substrate, as shown in the DF heterozygote. The appearance of an interaction product, like antigen I, at the expense of antigens A and D, affects the reaction significantly. Influences other than those of the particular locus are exerted by the genetic background, which may be responsible for the raw materials for gene product or the substrates for gene action. It appears so far, with reference to the Hg locus, that no other blood group locus exerts a pronounced influence upon the scores of cells tested for factors A, D, or F. The titer of an iso-antiserum and its ability to detect gene dosage effects are not dependent upon the donor-recipient pairing, as long as incompatibility exists.