VITAMIN-D UPTAKE BY THE PERFUSED-RAT-LIVER IS DETERMINED BY ITS TRANSPORT PROTEIN

  • 1 January 1982
    • journal article
    • research article
    • Vol. 7  (6) , 298-304
Abstract
Radiolabeled vitamin D3 and 25(OH)vitamin D3 (25(OH)D) were added to an isolated perfused rat liver, bound either to lipoproteins or lipoprotein-free plasma. The disappearance of vitamin D and 25(OH)D from the perfusate was determined. When vitamin D or 25(OH)D were added to the perfusate on lipoproteins there was a rapid decline in the amount present in the perfusate, as compared to when they were added bound to lipoprotein-free plasma. The uptake of vitamin D and 25(OH)D by the liver from lipoproteins was associated with a transfer of radioactivity from the lipoprotein portion to the lipoprotein-free portion of the perfusate. These results demonstrate the importance of the vitamin D transport protein to its uptake by the liver.

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