Comparison of the Dose- and Time-Survival Curves for Normal Hematopoietic and Lymphoma Colony-Forming Cells Exposed to Vinblastine, Vincristine, Arabinosylcytosine, and Amethopterin2

Publisher Website
Google Scholar
Abstract
Dose- and time-survival curves for normal hematopoietic and transplanted lymphoma colony-forming cells exposed in vivo to vinblastine, vincristine, amethopterin, and arabinosylcytosine were obtained. The dose-survival curves for all four agents given in 24 or 48 hours decreased with dose but reached saturation levels where further increase in dose produced no further decrease in survival. Dose schedules from the saturation portion of the curves were used to obtain the time-survival curves. Survival of the normal cells exposed to vinblastine, vincristine, and arabinosylcytosine decreased little for 12 hours, then decreased exponentially to about 1% at 48 hours. Survival of the lymphoma cells decreased rapidly to about 0.1 % at 12 hours, then less rapidly to about 0.01 % at 48 hours. The curves for normal cells exposed to amethopterin and the lymphoma cells exposed to vincristine differed from the others. Reasons for the similarities of most of the survival curves, possible explanations for the differences of some of the curves, and implications of the results in the use of the agents in chemotherapy are discussed.

This publication has 0 references indexed in Scilit: