Effect of Volatile Anesthetics on Protein Synthesis and Secretion by Rat Hepatocyte Suspensions
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Drug and Chemical Toxicology
- Vol. 9 (3-4) , 223-237
- https://doi.org/10.3109/01480548608998277
Abstract
The effect of volatile anesthetics on protein synthesis and secretion by isolated rat hepatocytes in suspension was investigated. Halothane and enflurane inhibited protein synthesis in a dose-dependent manner. Diethyl ether had little effect on protein synthesis while isoflurane caused a mild inhibition. This effect was more pronounced in hepatocytes from phenobarbital treated male rats when compared to hepatocytes from control rats. Protein synthesis in hepatocytes from phenobarbital treated female rats was inhibited similar to that seen with control male rat hepatocytes. Isoflurane, enflurane, and halothane also caused a dose-dependent inhibition of protein secretion, while diethyl ether was only mildy inhibitory. From these studies it appears that inhibition of protein synthesis and secretion might be an early and sensitive indicator of cellular injury by volatile anesthetics.This publication has 20 references indexed in Scilit:
- Acute Effects of Halothane and Enflurane on Drug Metabolism and Protein Synthesis in Isolated Rat HepatocytesActa Pharmacologica et Toxicologica, 2009
- HIGH CLINICAL CONCENTRATIONS OF HALOTHANE INHIBIT CELLULAR PROTEIN SYNTHESISAnesthesiology, 1985
- Effects of Anaesthetics on Protein Synthesis in Isolated Rat Hepatocytes: Inhibition by Diethyl Ether in Contrast to No Influence by Pentobarbital and FentanylActa Pharmacologica et Toxicologica, 1985
- Toxicity and Biotransformation of Volatile Halogenated Anesthetics in Rat Hepatocyte SuspensionsDrug and Chemical Toxicology, 1985
- The role of 5-aminolaevulinate synthase, haem oxygenase and ligand formation in the mechanism of maintenance of cytochrome P-450 concentration in hepatocyte cultureBiochemical Journal, 1983
- Reversible inhibition of protein synthesis in lung by halothaneBiochemical Journal, 1983
- Enflurane Effects on Cell Division and Macromolecular Synthesis in Tetrahymena pyriformisAnesthesiology, 1980
- Factors influencing halothane hepatotoxicity in the rat hypoxic modelToxicology and Applied Pharmacology, 1980
- Ascorbic acid deficiency and cytochrome P-450 in adult rat hepatocytes in primary monolayer cultureArchives of Biochemistry and Biophysics, 1979
- Halo thane Inhibition of RNA and Protein Synthesis of PHA-treated Human LymphocytesAnesthesiology, 1975