γ-Aminobutyric Acid Antagonists in Crustacea
- 1 October 1973
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 51 (10) , 774-775
- https://doi.org/10.1139/y73-117
Abstract
The potency of picrotoxin, bicuculline, and bicuculline methochloride as antagonists of the inhibitory actions of γ-aminobutyric acid on the discharge of the stretch receptor neurones and on neuromuscular transmission in crayfish have been examined. On the stretch receptor the three antagonists were roughly equipotent; at the neuromuscular junction however the bicucullines were considerably less effective than picrotoxin.Keywords
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