Flupirtine protects against ischaemic retinal dysfunction in rats

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Abstract
The present study investigated whether flupirtine attenuates the depression and enhances the recovery of the b-wave of the electroretinogram (ERG) in response to retinal ischaemia. The ERG was recorded from pentobarbital-anaesthetized rats before, during and after transient (24 min) occlusion of both common carotid arteries. Flupirtine administered 20 min before ischaemia reduced the depression of the b-wave during occlusion and accelerated recovery during reperfusion. When given at the onset of ischaemia flupirtine led to attenuation of the reduction of the b-wave during occlusion and to enhancement of the recovery during reperfusion. The present results suggest that flupirtine provides protection against ischaemic retinal dysfunction.

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