Nuclear magnetic resonance studies on the self-association of adenosine 5′-triphosphate in aqueous solutions
- 15 October 1977
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 55 (20) , 3620-3630
- https://doi.org/10.1139/v77-509
Abstract
The self-association of adenosine 5′-triphosphate (ATP) in aqueous, basic solutions has been studied. The results indicate that the monomer–dimer–trimer equilibrium model for base association fits the data well, but so does a model which includes higher order species. This indicates that the ATP molecules in solution can undergo indefinite linear self-association. The average value of the association constant based on the 1H and 31P chemical shift measurements is 0.9 ± 0.3 M−1. Longitudinal relaxation rates for the H8, H1′, and H2 protons of ATP were obtained as a function of the nucleotide concentration. The analysis of the viscosity-corrected proton H2 data yields an association constant of 5.1 ± 1.3 M−1.This publication has 6 references indexed in Scilit:
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