INHIBITORY EFFECT OF FUMARIC-ACID AND DICARBOXYLIC-ACIDS ON GASTRIC ULCERATION IN RATS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 226  (2) , 324-330
Abstract
Production of gastric ulcerations in rats by pyloric ligation was inhibited by either i.p. or oral administration of fumaric acid [Capsella bursa-pastoris] in a dose of 50 mg/kg. The antiulcer action was also exhibited by the 4-carbon dicarboxylic acids, maleic acid, oxalacetic acid, succinic acid and malic acid. Fumaric acid antiulcer action appears to be based on its ability to inhibit the gastric juice secretion and to dilate the stomach muscle.

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