AIDS Pathogenesis: A Finite Immune Response to Blame?
- 26 April 1996
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 272 (5261) , 505-506
- https://doi.org/10.1126/science.272.5261.505
Abstract
Some rare individuals infected with the HIV virus do not develop AIDS, and their immune systems remain healthy indefinitely. In a report in this issue of Science, Wolinsky et al. describe several indices of immune system function in six of these long-term survivors. In their Perspective, Miedema and Klein discuss what these exceptional cases reveal about the more usual course of events for infected individuals—collapse of the immune system and development of AIDS.Keywords
This publication has 15 references indexed in Scilit:
- ____________________________________________________________Science, 1996
- Adaptive Evolution of Human Immunodeficiency Virus-Type 1 During the Natural Course of InfectionScience, 1996
- Virus Burden in Long-Term Survivors of Human Immunodeficiency Virus (HIV) Infection Is a Determinant of Anti-HIV CD8+ Lymphocyte ActivityThe Journal of Infectious Diseases, 1995
- Are HIV-specific CTL responses salutary or pathogenic?Current Opinion in Immunology, 1995
- Antigenic oscillations and shifting immunodominance in HIV-1 infectionsNature, 1995
- Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.The Journal of Experimental Medicine, 1995
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionNature, 1995
- Antigenic Diversity Thresholds and the Development of AIDSScience, 1991
- AIDS pathogenesis: a dynamic interaction between HIV and the immune systemImmunology Today, 1990
- REPLICATIVE CAPACITY OF HUMAN IMMUNODEFICIENCY VIRUS FROM PATIENTS WITH VARYING SEVERITY OF HIV INFECTIONThe Lancet, 1986