A substance enhancing virus growth and antagonistic to interferon action

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Abstract
An interferon antagonist was obtained free of both cells and virus from a hamster cell line (BHK-21) infected with Sindbis virus. This material was also found to enhance Sindbis virus growth. A method for the assay of the interferon antagonist is described which is based on its capacity to reduce the activity of interferon as measured by a lack of reduction in Sindbis virus plaque numbers. The antagonist was found to be resistant to ribonuclease and deoxyribonuclease but sensitive to trypsin. Evidence for the existence of a similar substance in Sindbis virus infected chick embryo cell cultures was also obtained.

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