Comparative bioavailability and pharmacokinetics of noscapine hydrogen embonate and noscapine hydrochloride
- 1 January 1986
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 31 (3) , 367-369
- https://doi.org/10.1007/bf00981140
Abstract
The relative bioavailability and pharmacokinetics of two orally administered aqueous suspensions of noscapine hydrogen embonate were compared with those of noscapine hydrochloride solution. Noscapine hydrochloride showed faster absorption and gave a higher peak concentration than the embonate. The average bioavailability of the embonates was 71% of that of the noscapine solution (p<0.05). No significant difference was observed when the embonate was administered with water, polyvidone and flavouring agents.Keywords
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