Commentary: Mathematical models of cancer progression and epidemiology in the age of high throughput genomics

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Abstract
The major principles of genetics and evolution were developed before the structure of DNA was discovered in 1953. Darwin got pretty much everything right about evolution, despite his mistaken views on genetics. After the rediscovery of Mendel's theory, Fisher, Wright, and Haldane worked out the mathematical principles of mutation, selection, and evolutionary genetics during the first half of the 20th century. The spectacular accomplishments of modern molecular biology have greatly enriched understanding of genetics and evolution. However, the foundational principles of evolution and adaptation from the pre-molecular era remain the guidelines by which we interpret why biology appears as it does.

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