Differing Form of Variant Form of Hypergranular Promyelocytic Leukaemia (M3), or Transition between M3 and Monocytic Leukaemia?

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Abstract
A 17 yr old woman had acute myeloid leukemia (AML) with a leukocyte count of about 100 .times. 109/l. The great majority of the leukocytes were immature. About half of them were without granules; in the other half the granules were usually scanty; but occasionally numerous and rather coarse. A few cells had Auer rods arranged in bundles. The patient had uncompensated disseminated intravascular coagulation (DIC) with a severe tendency to bleed. Everything fitted with variant hypergranular promyelocytic leukemia, except for the staining of 30% of the immature cells by Loffler''s unspecific esterase with .alpha.-naphthyl acetate. The patient may be classified as a variant of variant form M3 or as a transition between M3 and acute monocytic leukemia.