Metabolism of dl-Adrenaline-2-C14 in the Human
- 1 July 1958
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 98 (3) , 627-630
- https://doi.org/10.3181/00379727-98-24129
Abstract
A procedure is described which utilizes a combination of filter paper and ion exchange chromatography to separate the urinary metabolic products of adrenaline. After intravenous infusion of dl-adrenaline-2-C14 in 6 human subjects, 73 ± 5% of infused radioactivity was recovered in 24 hour urine. Radioactivity which appeared in urine was distributed among various metabolic products as follows: adrenaline, 4%, 3-methyl-O-adrenaline, 5%, 3-methyl-O-adrenaline conjugate, 42 ± 7%; 3-methoxy-4-hydroxymandelic acid, 27 ± 3%; 3, 4-dihydroxymandelic acid, 12 ± 4%; 2 unidentified fractions, 4%.Keywords
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