In-Vivo Degradation of Poly(Lactic Acid) of Different Molecular Weights
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Biomaterials, Medical Devices, and Artificial Organs
- Vol. 13 (3-4) , 153-162
- https://doi.org/10.3109/10731198509118848
Abstract
Lactic acid was polymerized using tetraphenyl tin as a catalyst. The molecular weight of the resultant poly(lactic acid) varied between 0.89 × 106 and 2.94 × 106 depending upon the concentration of the catalyst used. In-vivo degradation of the poly(lactic acid) samples having 4 different molecular weights were studies by implanting these in Wistar rats. It was found that at the end of a 48-week implantation period lower molecular weight poly(lactic acid) samples were degraded at a faster rate than the higher molecular weight samples.This publication has 5 references indexed in Scilit:
- Sustained drug delivery systems. I. The permeability of poly(ϵ‐caprolactone), poly(DL‐lactic acid), and their copolymersJournal of Biomedical Materials Research, 1979
- Degradation rates of oral resorbable implants (polylactates and polyglycolates): Rate modification with changes in PLA/PGA copolymer ratiosJournal of Biomedical Materials Research, 1977
- A PARTIALLY BIODEGRADABLE VASCULAR PROSTHESISAsaio Journal, 1972
- Biodegradable poly(lactic acid) polymersJournal of Biomedical Materials Research, 1971
- Kinetik und Mechanismus der ringöffnenden Polymerisation von L(—)‐LactidDie Angewandte Makromolekulare Chemie, 1971