HEMOLYSIN RESPONSE IN THE RAT AFTER A SINGLE INTRAPERITONEAL INJECTION OF SHEEP ERYTHROCYTES

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Abstract
SUMMARY: An investigation has been made of the characteristics of the hemolysin response in rats after a single intraperitoneal injection of varied amounts of sheep erythrocytes.A detailed description of the hemolysin titration technic is given. The error of the method has been calculated and found to be small in comparison with the interindividual variation of the hemolysin response within groups of animals. The consequence of this circumstance for certain types of immunological research work is stressed.Previous work in this field has been confirmed with respect to the general type of the antibody curve. In addition the results suggest that larger doses of antigen gave an earlier maximum titer than smaller amounts. From the eighth day after the antigen injection and onwards the antibody curves seemed to assume a rather uniform slope.