Manganese Utilization and Placental Transfer in the Gravid Gilt

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Abstract
Fifteen yearling sows and 73 third trimester fetuses were used to study tissue-organ distribution and movement of stable Mn and retained 54Mn across placental membranes. Sows consuming 87 mg Mn per day excreted 62 mg and absorbed 28% of the daily intake. After 7 days 26% of the oral and 78% of the IV 54Mn dose was retained. 54Mn clearance by kidneys was greatest 45 to 60 min. postdosing, averaging 0.72 ml urine per minute and 0.3 mg Mn per day. Blood 54Mn disappearance was rapid, and after 5 min. only 25% of the injected dose remained in total blood. Liver served as a principal metabolic pool, reaching maximum 54Mn concentration 6 hr. post-dosing. Pregnancy had no significant effect upon maternal tissue retention, organ distribution or turnover rate. Fetal mass appeared to be a major factor affecting total Mn transfer. Third trimester litters contained 6.4 mg Mn; placenta, 1.4 mg, and total placental fluids 0.6 milligrams. After 168 hr., 25.7% of the retained 54Mn was transferred to the conception products, 87% of which was in the developing 110-day old fetuses. Copyright © 1971. American Society of Animal Science . Copyright 1971 by American Society of Animal Science.

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