THE DEPRESSANT ACTION OF STRYCHNINE ON THE SUPERIOR CERVICAL SYMPATHETIC GANGLION AND ON SKELETAL MUSCLE

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Abstract
The effect of strychnine on the superior cervical ganglion and on the neuromuscular junction was studied in cats. In both synapses, whatever the doses used, only a depressant effect was observed. This depression occurred in the responses to nerve impulses and to injected acetylcholine. Prostigmin counteracts partially the depressing effect of strychnine in either the ganglion or in striated muscle. An explanation of these data on the theory of chemical transmission is attempted.

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