The haemolytic activity of sols containing progesterone solubilized by phosphatidylcholine and lysophosphatidylcholine
- 1 December 1969
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 21 (Supplement) , 189S-194S
- https://doi.org/10.1111/j.2042-7158.1969.tb08373.x
Abstract
Lysis of rat erythrocytes by aqueous dispersions containing lysophosphatidylcholine (lpc), phosphatidylcholine (pc) and progesterone has been studied. The haemolytic activity of lpc was reduced by saturating it with progesterone; mixed lpc-pc micelles owed their lytic activity to the lpc alone. Cholesterol solubilized together with progesterone by lpc greatly reduced the lytic activity of the lpc, and when solubilized with progesterone by a 1:1 mixture of lpc and pc, prevented haemolysis. Triolein also inhibited the haemolytic properties of the sols.Keywords
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