LACK OF GASTROINTESTINAL METABOLISM OF PROPRANOLOL IN DOGS AFTER PORTACAVAL TRANSPOSITION

  • 1 January 1982
    • journal article
    • research article
    • Vol. 221  (2) , 512-515
Abstract
Propranolol may undergo presystemic metabolism in the gastrointestinal wall in dogs. Dogs (5) were studied before and 4 wk after creation of a portacaval transposition. Before surgery, systemic bioavailability of the oral dose was 8 .+-. 8% (mean .THETA. SD). After transposition, the bioavailability was 102 .+-. 9%. The systemic plasma clearance increased from 766 .+-. 192 to 976 .+-. 280 ml/min. The terminal half-life and apparent volume of distribution after transposition were not significantly different from those obtained preoperatively. There was apparently complete absorption but no metabolism of propranolol by the gastrointestinal wall.