On the mechanism of secretion of ions by gastric mucosa and by other tissues

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Abstract
Evidence is presented of the differences of potential observed between pairs of HgCl, AgCl and glass electrodes when one of a pair is in the "nutrient" soln., the other in the "secretory" soln., of isolated, non-secreting gastric mucosa of the frog. The values of these potential differences and their variation with composition of the secretory soln. have been interpreted in terms of the permeability of the mucosa to ions. An extended theory of the chemical and physicochemical mechanism of gastric secretion has been developed, in the light of present knowledge of the chemistry and thermodynamics of cellular processes. This is shown to be consistent with the evidence available concerning gastric secretion. In the light of this theory, other cases of ionic secretion are discussed.