Genetics of the HL‐A System A Population and Family Study

Publisher Website
Google Scholar
Abstract
Summary. A total of 973 unrelated Danes and Norwegians have been typed for a number of HL‐A iso‐antigens, and so have 150 Danish and Norwegian families with a total of 480 children. Two series of HL‐A iso‐antigens were investigated: the LA series with the antigens HL‐Al, 2, 3, Ba*, ILN*and LA4, and the Four series with the antigens HL‐A5, 7, 8, T12, R*, HN, FJH and BB. These antigens were inherited as co‐dominant characters with the exception of Ba*, ILN*, and R*, which were operationally recessive to HL‐A2, 3 and 5, respectively, but co‐dominant in respect of the other factors. No individuals carried more than two antigens from each series, and the family analysis yielded no evidence against the assumption that the antigens within each series are controlled by mutually exclusive genetic determinants: The LA and Four series represent two mutational sites within the HL‐A chromosomal region. No recombinations between these series were observed in this study, and the estimated upper limit of the recombination frequency between the corresponding sites was 0.84%. A total of 345 parental haplotypes could be unequivocally deduced; two of these, HL‐A (1, 8) and HL‐A (3, 7), occurred much oftener than should have been expected from the frequencies of the corresponding determinants, and there is thus linkage disequilibrium between the LA and Four series.