Structure activity-based predictive toxicology: an efficient and economical method for generating non-congeneric data bases
- 1 September 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Mutagenesis
- Vol. 6 (5) , 391-394
- https://doi.org/10.1093/mutage/6.5.391
Abstract
Starting with the results of the mutagenirity of 100 chemicals, we use CASE, a structure activity relational system, to select additional chemicals for inclusion into a data base. We demonstrate that a data base consisting of ∼ 180 carefully selected chemicals is as predictive as the analysis based upon 820 ‘unselected’ chemicals.Keywords
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