A Theory of Gradient Hydroxyapatite Chromatography: Approximate Calculation of Chromatograms Taking into Account Both Mutual Molecular Interactions and Longitudinal Diffusion

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Abstract
A method for the approximate calculation of theoretical chromatograms with gradient chromatography is proposed for a mixutre of molecules with the same dimensions and the same shape. Account is taken of both the mutal interactions among molecules adsorbed on the crystal surfaces of hydroxyapatite and the longitudinal molecular diffusion in the column. The parameter that is related to geometrical configurations of a molecule on the crystal surface is specified.