Effects of various selenium compounds on the development of muscular dystrophy and other vitamin E dyscrasias in the chick

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Abstract
Selenite, selenate, selenodicysteine, selenocystine, and selenomethionine, when administered orally, provided comparable protection against the development of nutritional muscular dystrophy in chicks fed a vitamin E deficient fat-free diet. When unsaturated lipid was included in the tocopherol-deficient basal ration, many of the control chicks not receiving selenium developed exudative diathesis as well as muscular dystrophy. Supplementation with either selenoamino acids, selenite, or selenate completely prevented exudates and provided the same degree of protection against muscle degeneration as obtained with the fat-free diet. Unexpectedly, however, when lard was fed, supplementation with selenite or selenate (but not the selenoamino acids), while alleviating exudates and dystrophy, provoked the onset of encephalomalacia.

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